Writers,Erasers and Readers in Lactylation Modification
10.13865/j.cnki.cjbmb.2025.05.1057
- VernacularTitle:乳酰化修饰中的Writers,Erasers与Readers
- Author:
Ying-Yan LI
1
;
Li-Yan CHEN
;
Yan-Hua JIN
Author Information
1. 延边大学医学院细胞生物学与医学遗传学教研室,吉林延吉 133002
- Publication Type:Journal Article
- Keywords:
post-translational modifications(PTMs);
lactylation;
lactyltransferases;
delactylases;
lacty-lation readers
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):925-932
- CountryChina
- Language:Chinese
-
Abstract:
Lactylation is a recently identified post-translational modification(PTM)that modulates gene expression and cellular functions by modifying lysine residues,and plays important roles in processes such as tumorigenesis,immune regulation,and metabolism.However,the regulatory mechanisms under-lying lactylation remain largely unclear,particularly regarding the enzymes responsible for adding"writ-ers",removing"erasers",and recognizing"readers"lactyl groups.This review systematically summari-zes recent advances in the study of these three types of regulators,highlighting their structural features,mechanisms of action,and biological functions.Moreover,it discusses their roles in the disease contexts,including cancer progression,immune evasion,and metabolic adaptation.By integrating current find-ings,this article aims to provide a theoretical basis for understanding the biological significance of lactyla-tion and to offer new perspectives for targeting lactylation in disease therapy.
