Research on the application of microwave thermochemotherapy in patients with early lip squamous cell carcinoma
10.3969/j.issn.1001-3733.2025.04.013
- VernacularTitle:微波热化疗在早期唇鳞状细胞癌患者中的应用研究
- Author:
Minqi ZHAO
1
;
Hao SONG
;
Yang LIU
;
Xinrui ZHANG
;
Guoxin REN
Author Information
1. 261000 潍坊,山东第二医科大学口腔医学院
- Publication Type:Journal Article
- Keywords:
Cancer of lip;
Microwave thermochemotherapy;
Surgery of lip cancer
- From:
Journal of Practical Stomatology
2025;41(4):514-518
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:This study aimed to compare the disease-free survival(DFS)and cervical lymph node metastasis risk in lip squamous cell carinoma(LSCC)patients between microwave thermochemotherapy and traditional surgical resection.Methods:A retrospective analysis was conducted on 106 eligible LSCC patients treated between January 2010 and January 2022.Patients were divided into the microwave thermochemotherapy group(n=37)and the surgery-alone group(n=69).Survival curves were generated using the Kaplan-Meier method,with DFS differences evaluated by Log-Rank test.Cox proportional hazards models and logistic re-gression were employed to screen prognostic factors and assess variables associated with cervical lymph node metastasis,respective-ly.Statistical analyses were performed using SPSS 26.0.Results:By September 2024,the objective response rate in the microwave thermochemotherapy group reached 94.59％(35/37).Survival analysis revealed no statistically significant difference in DFS be-tween the two groups(P=0.300).Multivariate logistic regression demonstrated that treatment modality was associated with cervical lymph node metastasis risk(P=0.022).The microwave thermochemotherapy group exhibiting a trend toward lower cervical lymph node metastasis rates compared to the surgery group.Conclusion:This study suggests that microwave thermochemotherapy achieves disease control efficacy comparable to surgical resection in early-stage LSCC patients and may reduce the likelihood of regional lymph node metastasis.
