Effects of probiotic-assisted minocycline on periodontal index,salivary flora concentration and oral health status in elderly patients with chronic periodontitis
10.3969/j.issn.1001-3733.2025.04.009
- VernacularTitle:益生菌辅助米诺环素对老年慢性牙周炎患者牙周指数、唾液菌群浓度及口腔健康状态的影响
- Author:
Yanru MA
1
;
Hengguo SONG
1
;
Shuang SONG
1
;
Jie YANG
1
;
Shiying LI
1
Author Information
1. 274000,菏泽医学专科学校附属医院口腔科
- Publication Type:Journal Article
- Keywords:
Chronic periodontitis;
Elderly;
Probiotics;
Minocycline;
Oral flora;
Periodontal index
- From:
Journal of Practical Stomatology
2025;41(4):490-494
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of probiotic-assisted minocycline in the treatment of elderly patients with chronic periodontitis(CP).Methods:95 elderly patients with CP in our hospital from January 2021 to March 2023 were selected and divided into observation group(49 cases)and control group(46 cases)by random number table method.Both groups received oral health education,the control group received standard periodontal treatment,the observation group was given probiotic lozenges,and both groups were treated for 4 weeks.The therapeutic effect and occurrence of adverse reactions in the 2 groups were analyzed,and the periodontal index[loss of attachment(AL),probing depth(PD),bleeding index(BI)],oral flora(concentrations of Lac-tobacillus salivary and porphyromonas gingivalis)and oral health status[oral health assessment tool(OH AT)score]before and after treatment were compared.Results:No cases were excluded in 2 groups.After treatment,the total effective rate of observation group was 95.92％higher than that of control group 80.43％(P＜0.05).After treatment,the values of AL,PD and BI in the 2 groups were lower than before treatment(P＜0.05),and the values of AL,PD and BI in the observation group were lower than those in the control group(P＜0.05).After treatment,the concentration of porphyromonas gingivalis in saliva in 2 groups was lower than that be-fore treatment,and the concentration of lactobacillus in saliva was higher than that before treatment(P＜0.05).The concentration of porphyromonas gingivalis in saliva in observation group was lower than that in control group,and the concentration of lactobacillus in saliva was higher than that in control group(P＜0.05).After treatment,the OH AT score of the 2 groups was lower than that before treatment(P＜0.05),and the OHAT score of the observation group was lower than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Probiotics assisted mino-cycline in the treatment of elderly patients with CP can reduce periodontal index,regulate oral flora and improve oral health without increasing adverse reactions.
