A case of leucine-rich glioma-inactivated 1 antibody-associated encephalitis following coronavirus disease 2019 infection
10.3760/cma.j.cn113661-20231007-00123
- VernacularTitle:新型冠状病毒感染后富亮氨酸胶质瘤失活1蛋白抗体相关脑炎1例
- Author:
Yan SHAO
1
;
Yi CHEN
;
Jing CHEN
;
Shichang WANG
;
Xinyu SUN
Author Information
1. 北京大学第六医院 北京大学精神卫生研究所 国家卫生健康委员会精神卫生学重点实验室（北京大学）国家精神心理疾病临床医学研究中心（北京大学第六医院）国家精神疾病医学中心（北京大学第六医院），北京 100191
- Publication Type:Journal Article
- Keywords:
Cognition disorders;
Encephalitis;
Leucine rich glioma inactivated 1-antibody;
Coronavirus disease 2019
- From:
Chinese Journal of Psychiatry
2024;57(6):371-376
- CountryChina
- Language:Chinese
-
Abstract:
This is a case report of a 70-year-old male patient with rapid progression of cognitive dysfunction, sleep behavior disturbance, emotional instability, and motor disturbance after COVID-19 infection. The patient was diagnosed with "depressive state, manic state, and dementia cause unknown", antidepressants and mood stabilizers were ineffective. Both serum and cerebrospinal fluid were positive for anti-leucine-rich glioma-inactivated protein 1 (LGI1) antibodies, and "LGI1 antibody-associated encephalitis" was confirmed. All symptoms improved significantly after immunoglobulins and glucocorticoids therapy. In this case, by reviewing the clinical characteristics of LGI1 antibody-associated encephalitis after COVID-19 infection, we can improve the understanding of the disease, as well as reduce misdiagnosis and mistreatment.
