Cyclophosphamide-induced hyponatremia
10.3760/cma.j.issn.1008-5734.2017.02.015
- VernacularTitle:环磷酰胺致低钠血症
- Author:
Ruituan GUO
1
;
Gailian ZHANG
;
Liyun ZHANG
;
Jinfang GAO
;
Dan MA
Author Information
1. 山西医科大学研究生院, 太原,030001
- Publication Type:Journal Article
- Keywords:
Cyclophosphamide;
Hyponatremia
- From:
Adverse Drug Reactions Journal
2017;19(2):138-139
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old female patient with systemic lupus erythematosus received an IV infusion of cyclophosphamide for four times (the therapeutic dose of 200, 400, 200, 400 mg, there were 8 days apart between the first and the second medication, there were 12 days apart between the second and the third medication, there were 29 days apart between the third and the fourth medication).There were no symptoms after first administration.On day 2 of the second administration, the patient showed limb shaking and sweating.The serum sodium decreased from 127 mmol/L before treatment to 107 mmol/L.Hyponatremia associated with cyclophosphamide was considered.Continuous intravenous pumping of concentrated sodium 2.3 g was given.Four days later, her serum sodium was 133 mmol/L, concentrated sodium was replaced by oral salt capsules one pill thrice daily.The level of serum sodium decreased slightly after the third and the fourth administrations then returned to normal levels after giving salt capsules.
