Drug hypersensitivity syndrome induced by sodium valproate
10.3760/cma.j.issn.1008-5734.2017.02.017
- VernacularTitle:丙戊酸钠致药物超敏反应综合征
- Author:
Shipeng ZHAN
1
;
Min TANG
1
Author Information
1. 第三军医大学第一附属医院药学部, 重庆,400038
- Publication Type:Journal Article
- Keywords:
Valproic acid;
Hypersensitivity
- From:
Adverse Drug Reactions Journal
2017;19(2):142-143
- CountryChina
- Language:Chinese
-
Abstract:
A 20-year-old male with athetosis received sodium valproate 500 mg twice daily.Twenty days after treatment, the patient developed general erythematous which faded after pressing, increased skin temperature, facial swelling, and enlargement of uperficial lymph node in his head and neck.Laboratory tests showed the following values: white blood cell (WBC) 18.3×10 9/L, neutrophils 0.392, lymphocytes 0.364, monocytes 0.137, eosinophils 0.097, procalcitonin (PCT) 0.3 μg/L, alanine aminotransferase (ALT) 311 U/L, aspartate aminotransferase (AST) 148 U/L, alkaline phosphatase (ALP) 295 U/L, gamma-glutamyl transferase (γ-GT) 169 U/L.The patient was diagnosed as drug induced hypersensitivity syndrome (DIHS).Valproate was withdrawn.He received the symptomatic reatments which included glucocorticoid, antihistamines, liver protection and topical medication.Twenty days later, his erythematous rash were disappeared mainly.Fifty-five days later, his erythematous rash disappeared completely.Laboratory tests showed the following values: WBC 8.6×10 9/L, eosinophils 0.005, ALT 32 U/L, AST 22 U/L, ALP 66 U/L, γ-GT 67 U/L.
