Anaphylactic shock leading to death induced by lappaconite hydrobromide for injection
10.3760/cma.j.issn.1008-5734.2017.02.019
- VernacularTitle:注射用氢溴酸高乌甲素致过敏性休克死亡
- Author:
Yan HE
1
;
Deping CAO
;
Fen CHEN
Author Information
1. 405400,重庆市开州区人民医院药剂科
- Publication Type:Journal Article
- Keywords:
Lappaconite hydrobromide;
Anaphylaxis
- From:
Adverse Drug Reactions Journal
2017;19(2):145-147
- CountryChina
- Language:Chinese
-
Abstract:
A 26-year-old female patient with excision of left breast fibroma received an Ⅳ infusion of lappaconite hydrobromide 8 mg in glucose and sodium chloride 500 ml once daily.No abnormality was found for the first time.About 20 minutes after Ⅳ infusion on the next day, the patient developed dry throat, slight dyspnea.Her respiratory rate was 25 times/min, heart rate was 55 beats/min and blood pressure was 70/55 mmHg.Lappaconite hydrobromide was discontinued immediately.She was given oxygen inhalation of 2 L/min, intravenous injection of adrenaline 0.5 mg, intravenous injection of adrenaline 10 mg, intramuscular injection of diphenhydramine 20 mg and IV infusion of dopamine 200 mg.After 5 minutes, the patient lost consciousness, had weak breathing, facial cyanosis and no pulsate.The electrocardiogram monitor displayed isoelectric line.The patient was treated with cardiopulmonary resuscitation, endotracheal intubation and ventilator support, chest compression, intravenous of epinephrine and infusion of hydrocor-tisone.The pathogenetic condition was getting worse progressively.The patient eventually died after 3 hours rescue.
