Death attributed to severe anaphylactic reaction due to omeprazole
10.3760/cma.j.issn.1008-5734.2017.02.020
- VernacularTitle:奥美拉唑引发严重过敏反应致死亡
- Author:
Zhihong QIU
1
;
Yinling MA
1
;
Lien HE
1
;
Zhanjun DONG
1
Author Information
1. 河北省人民医院药学部, 石家庄,050051
- Publication Type:Journal Article
- Keywords:
Omeprazole;
Anaphylaxis;
Death
- From:
Adverse Drug Reactions Journal
2017;19(2):147-148
- CountryChina
- Language:Chinese
-
Abstract:
A 61-year-old female patient with stomach discomfort received omeprazole enteric coated tablet 40 mg once daily.On day 3 of administration of omeprazole, she presented sporadic erythema and stopped the medicine by herself.Three days after drug withdrawal, her symptom of erythema improved.She received omeprazole enteric coated tablet at the previous dosage again.Two days after taking medicine again, the patient developed rash all over her body, severe diarrhea and vomiting, acute renal injury and allergic shock in succession.She was diagnosed as severe allergic reaction due to omeprazole.The patient received the treatments of antianaphylaxis, maintaining the function of circulatory system, fluid infusion, and continuous veno venous hemodiafiltration.But the therapeutic effect was poor.The patient died on the second day after giving up the treatment which decided by her family members.
