The Role of LSD1 In Gynecologic Oncology
10.13865/j.cnki.cjbmb.2025.03.1427
- VernacularTitle:赖氨酸特异性组蛋白去甲基化酶1在妇科肿瘤中的作用
- Author:
Wan-Yun LI
1
;
Yan-Hua JIN
;
Yun-He PIAO
Author Information
1. 延边大学医学院细胞生物学与医学遗传学教研室,吉林延吉 133002
- Publication Type:Journal Article
- Keywords:
lysine specific histone demethylase(LSD 1);
demethylation;
tumor;
inhibitor
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):979-986
- CountryChina
- Language:Chinese
-
Abstract:
Lysine-specific demethylase 1(LSD1),a member of the flavin-dependent amine oxidase fam-ily,is a crucial"eraser"of lysine methylation.It reversibly removes methyl groups from histone H3K4me1/2 and H3K9me1/2,thereby regulating gene expression and chromatin function.Located with-in the nucleus,LSD 1 influences various biological processes in tumors,including proliferation,invasion,and metastasis.Previous studies have demonstrated that LSD1 is significantly overexpressed in gynecolog-ical cancers such as ovarian cancer,cervical cancer,and endometrial cancer,and its overexpression is closely associated with poor patient survival and unfavorable prognosis.Research indicates that LSD1 may promote tumor cell proliferation,invasion,and metastasis through the PI3K/AKT and mTOR signaling pathways,while also suppressing tumor cell autophagy and immune surveillance,contributing to immune evasion.In cervical cancer,LSD1 interacts with HPV16 E7,facilitating the epithelial-mesenchymal tran-sition(EMT)process.Furthermore,LSD1 inhibitors have shown promising therapeutic potential in ani-mal studies,particularly in restoring the sensitivity of ovarian cancer cells to platinum-based chemothera-py.This review summarizes the molecular mechanisms,functional targets,and associated signaling path-ways of LSD1 in gynecological cancers,as well as the mechanisms of action of various LSD1 inhibitors,aiming to provide new insights for targeted therapies in gynecological malignancies.
