Biological Characteristics and Functions of TRIM37 and Its Relationship with Disease Development
10.13865/j.cnki.cjbmb.2025.03.1469
- VernacularTitle:三结构域蛋白质37蛋白生物学特征和功能及与疾病发生的关系
- Author:
Jun-Rui LUO
1
;
Zhi-Qiang LIU
1
Author Information
1. 河南理工大学医学院基础医学部生物化学与分子生物学教研室,河南焦作 454000
- Publication Type:Journal Article
- Keywords:
tripartite motif-containing protein 37(TRIM37);
ubiquitination;
centrosome;
autophagy;
cancer
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):967-978
- CountryChina
- Language:Chinese
-
Abstract:
Tripartite motif-containing protein 37(TRIM37)is a multifunctional protein.It is an E3 ubiquitin ligase that primarily localizes to the peroxisome membrane and centrosome.It plays a crucial role in centrosome assembly,which is essential for spindle formation and the accuracy of chromosome segregation,ultimately affecting cell division.By ubiquitinating a variety of substrate proteins,TRIM37 regulates ubiquitination pathways and influences several key signaling pathways.Notably,it is involved in the activation of the mechanistic target of rapamycin complex 1(mTORC1)signaling pathway and reg-ulates autophagy by phosphorylating transcription factor EB(TFEB)via mTORC1.Furthermore,TRIM37 is integral to inflammatory and immune responses,as well as cell proliferation and apoptosis,through the activation of the nuclear factor kappa B(NF-κB)signaling pathway.It is also implicated in the regulation of other critical signaling pathways,such as Wnt/β-catenin and phosphatidylinositol-3-ki-nase/Protein Kinase B(PI3K/AKT),particularly in the context of cancer.TRIM37 enhances the prolif-eration,metastasis,and invasion of tumor cells,including those in gallbladder cancer,renal cell carci-noma,and glioma,and is linked to resistance against certain anticancer drugs.In sum,the diverse and complex functions of TRIM37 underscore its significance in various physiological and pathological proces-ses.This article reviews the biological role of TRIM37 and its association with diseases,focusing on its structure,function,involvement in cell autophagy,and the main signaling pathways.We aim to enhance the understanding of TRIM37-related disease pathogenesis and to identify potential new targets for future therapeutic research.
