The Mechanism by Which Maternal Metabolites Mediate Histone Modification to Regulate the Occurrence of Neural Tube Defects
10.13865/j.cnki.cjbmb.2025.04.1507
- VernacularTitle:母体代谢物介导组蛋白修饰调控神经管畸形发生的机制
- Author:
Zeng-Li LIU
1
;
Jian-Ting LI
1
;
Zhi-Zhen LIU
1
Author Information
1. 山西医科大学生物化学与分子生物学教研室山西省出生缺陷与细胞再生重点实验室,太原 030001;煤炭环境致病与防治教育部重点实验室,太原 030001
- Publication Type:Journal Article
- Keywords:
neural tube defects(NTDs);
histone modifications;
maternal metabolites;
methylation;
acetylation
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):956-966
- CountryChina
- Language:Chinese
-
Abstract:
Neural tube defects(NTDs)are a category of severe congenital birth defects that seriously af-fect the life and health of the fetus.The occurrence mechanism is very complex,involving the complex interaction between genetic factors and environmental factors.In recent years,the increasingly wide-spread application of proteomics has revealed the key role of histone modifications in epigenetic regula-tion,especially in the pathogenesis of NTDs.Histone modifications include various types such as histone methylation,acetylation,ubiquitination,homocysteinylation,malonylation,and crotonylation.These modifications affect the expression of key proteins involved in neural tube closure and are crucial for ge-nomic stability during neural tube closure,participating in the occurrence and development of NTDs.Ab-normal regulation of these regulations is closely related to the occurrence of NTDs.In addition,during embryonic brain development,histone modifications are easily affected by environmental factors such as maternal metabolite levels and exposure to teratogenic substances.Abnormal maternal metabolite levels can cause abnormal regulation of key gene expression,which affects histone modifications and thereby regulates the abnormal expression of downstream related genes,including genes related to neural tube de-velopment,leading to the occurrence of NTDs and other neurodevelopmental diseases.Although there have been numerous studies on the mechanism of NTDs,the exact pathogenesis of NTDs has not yet been fully elucidated.In-depth research on the pathogenic factors and occurrence mechanism of NTDs is of great significance for improving the quality of the birth population and reducing neonatal mortality.This article reviews the research progress in recent years on the occurrence of fetal NTDs caused by abnormal histone modifications mediated by maternal metabolites and provides a prospect for the future research di-rection.With the aim of revealing the key regulatory function of histone modifications in neural tube de-velopment,this review also provides a theoretical basis for further research on the relationship between histone modifications and the occurrence of NTDs,and for the future prevention and treatment strategies of NTDs.
