Hypertensive emergency caused by iopamidol
10.3760/cma.j.issn.1008-5734.2017.01.018
- VernacularTitle:碘帕醇致高血压急症
- Author:
Haixia LIANG
1
;
Jianbo ZHOU
;
Shengpeng ZHANG
;
Ying ZHU
;
Zhihui SONG
Author Information
1. 100088,首都医科大学附属北京安定医院药学部
- Publication Type:Journal Article
- Keywords:
Iopamidol;
Hypertension;
malignant
- From:
Adverse Drug Reactions Journal
2017;19(1):67-68
- CountryChina
- Language:Chinese
-
Abstract:
A 52-year-old female patient with hypertension and diabetes mellitus had mild and moderate arterial lesions of bilateral lower extremities. The computed tomographic angiography ( CTA) was performed to clarify the degree of vascular stenosis. Before examination, this patient′s blood pressure was 135/73 mmHg. She was given intraarterial iopamidol [37 g(I) /100 ml] 65 ml. About one hour after the intraarterial injection, she experienced dizziness, nausea, vomiting and fatigue, her blood pressure increased to 183/93 mmHg. After taking antihypertensive drugs for about one hour, those symptoms relieved and blood pressure was 150/90 mmHg. At about 5. 5 hours, the above clinical symptoms reappeared and blood pressure rose to 260/120 mmHg. Urapidil 100 mg was administered through continuous intravenous pump and the pump speed was 3. 0-6. 0 mg/h. After 3. 5 hours of treatment, the blood pressure decreased to 160/80 mmHg and the clinical symptoms of dizziness, nausea and vomiting disappeared. Therefore urapidil was stopped and captopril 12. 5 mg was temporarily orally administered. Though the constant adjustment of antihypertensive therapy, the patient′s blood pressure was stable at 140-150/70-80 mmHg.
