Acute toxicity due to overdosage of sodium valproate and ziprasidone
10.3760/cma.j.issn.1008-5734.2017.01.021
- VernacularTitle:超剂量服用丙戊酸钠及齐拉西酮致急性中毒
- Author:
Gangying CHENG
1
;
Aiping DENG
1
;
Yi WANG
1
;
Jue LIU
1
;
Qing ZHOU
1
Author Information
1. 430014,华中科技大学同济医学院附属武汉中心医院药学部
- Publication Type:Journal Article
- Keywords:
Poisoning;
Valproic acid;
Ziprasidone
- From:
Adverse Drug Reactions Journal
2017;19(1):74-75
- CountryChina
- Language:Chinese
-
Abstract:
A 45-year-old man with about 10 years of drug abuse history took 96 tablets of sodium valproate sustained-release ( 48 g ) and about 20 capsules of ziprasidone hydrochloride (>400 mg ) by himself one time. He appeared comatous and had no response to being called, then he was sent to the hospital by his family members. He presented no autonomous respiration, hypotonia of the four limbs and neck (2 level) on admission. He received symptomatic supportive treatments including tracheal intubation and ventilator assisted breathing, gastric lavage, coloclyster, fluid infusion, diuresis, and central nervous system stimulant, immediately. Two hours later, the patient awoke. Laboratory tests revealed the following results:arterial oxygen partial pressure (PaO2) 292 mmHg (1 mmHg=0. 133 kPa), lactic acid 5. 70 mmol/L, D-dimer 7. 8 mg/L, plasma fibrinogen degradation product (FDP) 45 mg/L. Twenty-four hours later, laboratory tests revealed the following results:PaO298 mmHg, lactic acid 1. 7 mmol/L, D-dimer 2. 2 mg/L, FDP 19 mg/L. The trachea cannula was removed. Forty-eight hours later, his consciousness returned to normal. He could finish the common action. But he still had the symptom of drowsiness. Seven days later, the patient could answer questions accurately. His muscular tension returned to normal. He had light drowsiness occasionally.
