Development of a list of high-alert medications for the Chinese children
10.3760/cma.j.issn.1008-5734.2017.01.004
- VernacularTitle:中国儿童高警示药品目录的初步研制
- Author:
Chunxiang WANG
1
;
Xiaoling WANG
;
Xiaoling LI
;
Huayu LIANG
;
Yuqin WANG
Author Information
1. 北京市怀柔区妇幼保健院
- Publication Type:Journal Article
- Keywords:
High-alert medication list;
Children;
China
- From:
Adverse Drug Reactions Journal
2017;19(1):10-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a list of high-alert medications for the Chinese children and provide reference for medication safety in children. Methods Based on the list of Children′s high-alert medications of the United States of America, the Netherlands, and Spain, and combined with the data of serious adverse drug reactions ( ADR) in children derived from literature published in China and abroad, serious ADR reports from ADR monitoring center of Beijing, Guangdong, Anhui, Hunan, and the People′s Liberation Army, medication errors in children from the International Network for the Rational Use of Drugs, prescription data from "Hospital Prescription Analysis Collaborative Project", we created a preliminary list of high-alert medications for children in China. The preliminary list was argued by expert consultation using Delphi technique. Thirty two experts were invited in the round 1 consultation, and according to the expert advices, the preliminary list was adjusted and the revised list formed. Thirty two experts were also invited in the round 2 consultation, according to the expert advices, the revised list was adjusted and the final version of the list of high-alert medications for Chinese children formed. Results A total of 17 classes and 55 kinds of drugs were entered into the list of high-alert medications for Chinese children, each drug had 1-4 risk points and one piece of advice. The average value of the familiarity of each expert with drugs was>0. 60;the average value of judgment basis for each expert was>0. 70;the average value of authority for each expert was >0. 70. The number of survey indexes in round 1 was 63, the expert coordination coefficient was 0. 18. The number of survey indexes in round 2 was 59, experts coordination coefficient was 0. 24. The difference between the coordinate coefficient in the 2 rounds of experts consultation was statistically significant (χ2=516. 424, P<0. 05;χ2=721. 635, P<0. 05). Conclusion The list of high-alert medications for children in China was developed preliminarily and may be used as a tool to promote medication safety and reduce the risk of medication for children in China.
