Distribution and antibiotic resistance profiles of clinical bacterial isolates in Beijing Children's Hospital,Capital Medical University from 2016 to 2022
10.16718/j.1009-7708.2025.01.009
- VernacularTitle:2016-2022年首都医科大学附属北京儿童医院临床分离细菌分布及耐药监测
- Author:
Zhiyong LÜ
1
;
Fang DONG
1
;
Qingying MENG
1
;
Jinghui ZHEN
1
;
Wei ZHOU
1
;
Xiqing LIU
1
;
Jingyun AN
1
Author Information
1. 国家儿童医学中心首都医科大学附属北京儿童医院检验中心,北京 100045
- Publication Type:Journal Article
- Keywords:
children;
bacteria;
antimicrobial agent;
bacterial resistance surveillance
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(1):59-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and antibiotic resistance profiles of clinical isolates in Beijing Children's Hospital,Capital Medical University from 2016 to 2022.Methods All the strains isolated from inpatients in Beijing Children's Hospital during the period from 2016 to 2022 were analyzed.Antimicrobial susceptibility test was conducted by Kirby-Bauer method or automated system.Results were interpreted according to the breakpoints recommended in the CLSI Ml00 2022 edition.Results A total of 24 904 isolates were analyzed,including Gram-positive bacteria(49.4％)and Gram-negative bacteria(50.6％).The top three Gram-positive bacteria were Staphylococcus aureus(15.6％),coagulase-negative Staphylococcus(14.0％),and Streptococcus pneumoniae(8.9％).The top three Gram-negative bacteria were Klebsiella spp.(8.6％),Pseudomonas aeruginosa(8.6％),and Haemophilus influenzae(8.1％).The prevalence of methicillin-resistant strains was 30.9％in SS.aureus(MRSA)and 82.7％in coagulase-negative Staphylococcus(MRCNS).The prevalence of PRSP was 75.0％(24/32)in meningitis isolates and 2.6％(57/2 195)in non-meningitis isolates.Five strains of E.faecium and 10 strains of E.faecalis were found resistant to linezolid.Two strains of E.faecium were resistant to vancomycin.The prevalence of extended-spectrum beta-lactamases(ESBLs)and carbapenem-resistant strains(CREco)in E.coli isolates was 69.0％and 9.7％,respectively.The prevalence of ESBLs and carbapenem-resistant strains(CRKpn)in K.pneumoniae isolates was 73.7％,and 37.2％,respectively.The prevalence of carbapenem-resistant strains was 21.9％in P.aeruginosa isolates and 59.3％in A.baumannii isolates.β-lactamase was detected in 68.3％of the H.influenzae isolates.Conclusions Antimicrobial resistance is still serious in children.It is necessary to strength the surveillance of bacterial resistance and use antibiotics rationally in order to curb the spread of drug-resistant strains.
