Clinical characteristics and antimicrobial susceptibility of 75 clinical strains of Cryptococcus neoformans
10.16718/j.1009-7708.2025.01.004
- VernacularTitle:75株临床分离新型隐球菌药物敏感性及临床分析
- Author:
Xiangyu GUAN
1
;
Junhao ZHU
;
Li YAN
;
Li LI
;
Demin HAN
;
Qiangqiang ZHANG
;
Min ZHU
Author Information
1. 复旦大学附属华山医院皮肤科真菌室,上海 200040;张家港市中医医院检验科
- Publication Type:Journal Article
- Keywords:
Cryptococcus neoformans;
antifungal susceptibility;
minimum inhibitory concentration;
cryptococcosis
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the susceptibility of Cryptococcus neoformans strains to antifungal drugs and examine the relevant clinical manifestations and laboratory test results in a tertiary hospital in Shanghai during the period from 2019 to 2023.Methods The isolates were identified by MALDI-TOF and biochemical identification cards.The minimum inhibitory concentration(MIC)values of 5-fluorocytosine,amphotericin B,fluconazole,voriconazole,and itraconazole against C.neoformans strains were measured using broth microdilution method.The corresponding clinical data were reviewed and compared.Results Majority(78.7％)of the 75 strains of C.neoformans were isolated from cerebrospinal fluid(CSF).The prevalence of wild type(WT)strains was the lowest(36.0％)for itraconazole and the highest(94.7％)for voriconazole.Cryptococcus capsular antigen test was positive in 62 strains.The results of Cryptococcus capsular antigen test was consistent with fungal culture in 96.9％of the cases.Conclusions Most of the C.neoformans strains were isolated from CSF.The prevalence of non-WT C.neoformans strains was the highest for itraconazole.The prevalence of WT C.neoformans strains was the highest for voriconazole.
