Research advances in exosomes for diagnosis and treatment of depression

VernacularTitle:外泌体在抑郁症诊治中的研究进展
Author: Kun LI ¹ ; Shuxian XU ; Lihong ZHANG ; Kun WANG ; Zhongchun LIU
Author Information

1. 武汉大学人民医院精神卫生中心，武汉430060
Publication Type:Journal Article
Keywords: Depressive disorder; Exosomes; Biomarker; Pathogenesis
From: Chinese Journal of Psychiatry 2024;57(5):267-273
CountryChina
Language:Chinese
Abstract: Exosomes are extracellular vesicles secreted by cells containing various biologically active substances, including proteins, lipids and nucleic acids. In the brain, exosomes participate in many physiological processes, such as neurogenesis, synaptic plasticity, and intercellular communication, and are closely associated with the development of depression. As exosomes can traverse the blood-brain barrier and be extracted in various peripheral body fluids, exosomes of central nervous system origin may facilitate understanding the pathophysiology of brain-related disorders. This review summarizes the role of exosomes in the common pathogenesis of depression, and it also discusses the great potential as biomarkers for early depression diagnosis and precision medicine, aiming to provide novel perspectives for depression research.