Influential factors and adverse reactions of antiviral therapy in teenagers with HIV/AIDS
10.3760/cma.j.issn.1008-5734.2016.02.006
- VernacularTitle:青少年HIv/AIDs患者抗病毒治疗的不良反应及影响因素
- Author:
Zhisheng LIU
1
;
Xingli LI
;
Jianmei HE
;
Xiuqing WEI
;
Jun ZHENG
;
Junshi ZHAO
;
Xi CHEN
Author Information
1. 中南大学公共卫生学院流行病与卫生统计学系, 长沙,410078
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiencY sYndrome;
Antiviral agents;
Drug toxicitY;
Adolescent
- From:
Adverse Drug Reactions Journal
2016;18(2):105-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the occurrence of adverse reactions and its influencing factors in the teenagers aged 12 to 24 Years who received 1 Year or more longer antiviral therapY. Methods national Information sYstem for AIDs Control and Prevention was searched and the data of teenagers and Young adults aged 12 to 24 Years with HIv/AIDs treated in Hunan Province from October 1,2003 to October 31,2013 were collected. The information included sex,age,marital status,route of infection,interval between diagnosis and treatment,with or without sYmptoms and signs at the beginning of treatment,opportunistic infection,clinical stages,counts of peripheral blood CD4 ﹢T lYmphocYtes( CD4 cells),initial treatment plan,and the tYpe and incidence rate of adverse reactions in each month during the first Year of treatment. The related factors between antiviral therapY and the adverse reactions were analYzed bY Logistic regression model. Results A total of 559 patients were enrolled into this studY. Of them,312 were males and 247 were females with the average age(22 ± 2)Years. The route of infection was sexual transmission accounting for 90. 9%(508/559). The number of cases with peripheral blood CD4 cell count ≥200 accounted for 55. 1%(300/544). The singles accounted for 65. 5%(366/559). The interval between diagnosis and treatment was from 0 to 1 859 daYs and an average time was 198 daYs,median time was 53 daYs. At the beginning of treatment ,the number of cases with sYmptoms and signs accounted for 29. 7%(166/559), associated opportunistic infections accounted for 28. 8%(169/589),and the clinical stages of Ⅰ,Ⅱ,Ⅲ, andⅣ accounted for 266(50. 5%),124(23. 5%),99(18. 8%),and 38(7. 2%),respectivelY. The initial treatment plans for the patients of male,female,12-18 Years,and 19-24 Years were mainlY lamivudine﹢zidovudime﹢nevirapine,theY accounted for 45. 2%(141/312),37. 2%(92/247),45. 9%(45/98), and 40. 8%(188/461),respectivelY. The incidence of adverse reactions in the first month during the treatment was the highest which accounted for 19. 3%( 108/559 ), including nausea and vomitting (37. 0%,40/108),erYthema(34. 3%,37/108),and fatigue(28. 7%,31/108). The incidence of adverse reactions in the second month during the treatment was 11. 7%( 57/486 ),including erYthema (35. 1%,20/57),fatigue(26. 3%,15/57)and appetite changes(24. 6%,14/57). thereafter,the incidences of adverse reactions of each month were lower than 10. 0%. The results of single factor analYsis for correlative factors of adverse reactions in the first month during the treatment showed age,sex,route of infection,with or without sYmptoms and signs at the beginning of treatment,with or without opportunistic infection,clinical stages and number of CD4 cells were related to the adverse reactions(all P﹤0. 05 ). The result of multi factor Logistic regression analYsis showed age 19-24 Years old(OR=1. 782,95%CI:1. 293-3. 554,P=0. 002),female(OR=1. 904,95%CI:1. 204-3. 013,P=0. 006),with sYmptoms and signs at the beginning of treatment(OR=3. 025,95%CI:1. 902-4. 810,P=0. 000)were the risK factors of the adverse reactions. Conclusions The mail adverse reactions of antiviral therapY in patients aged 12-24 Years during the first Year's treatment were gastrointestinal reaction and sKin lesions. The incidence of the adverse reactions in the first month during the treatment was the highest. Age 19-24 Years,female,and with sYmptoms and signs at the beginning of treatment are the the risK factors of the adverse reactions.
