Changing resistance profiles of Haemophilus influenzae and Moraxella catarrhalis isolates in hospitals across China:results from the CHINET Antimicrobial Resistance Surveillance Program,2015-2021
- VernacularTitle:2015-2021年CHINET临床分离流感嗜血杆菌和卡他莫拉菌的耐药性变迁
- Author:
Hui FAN
1
;
Chunhong SHAO
;
Jia WANG
;
Yang YANG
;
Fupin HU
;
Demei ZHU
;
Yunsheng CHEN
;
Qing MENG
;
Hong ZHANG
;
Chun WANG
;
Fang DONG
;
Wenqi SONG
;
Kaizhen WEN
;
Yirong ZHANG
;
Chuanqing WANG
;
Pan FU
;
Chao ZHUO
;
Danhong SU
;
Jiangwei KE
;
Shuping ZHOU
;
Hua ZHANG
;
Fangfang HU
;
Mei KANG
;
Chao HE
;
Hua YU
;
Xiangning HUANG
;
Yingchun XU
;
Xiaojiang ZHANG
;
Wenen LIU
;
Yanming LI
;
Lei ZHU
;
Jinhua MENG
;
Shifu WANG
;
Bin SHAN
;
Yan DU
;
Wei JIA
;
Gang LI
;
Jiao FENG
;
Ping GONG
;
Miao SONG
;
Lianhua WEI
;
Xin WANG
;
Ruizhong WANG
;
Hua FANG
;
Sufang GUO
;
Yanyan WANG
;
Dawen GUO
;
Jinying ZHAO
;
Lixia ZHANG
;
Juan MA
;
Han SHEN
;
Wanqing ZHOU
;
Ruyi GUO
;
Yan ZHU
;
Jinsong WU
;
Yuemei LU
;
Yuxing NI
;
Jingrong SUN
;
Xiaobo MA
;
Yanqing ZHENG
;
Yunsong YU
;
Jie LIN
;
Ziyong SUN
;
Zhongju CHEN
;
Zhidong HU
;
Jin LI
;
Fengbo ZHANG
;
Ping JI
;
Yunjian HU
;
Xiaoman AI
;
Jinju DUAN
;
Jianbang KANG
;
Xuefei HU
;
Xuesong XU
;
Chao YAN
;
Yi LI
;
Shanmei WANG
;
Hongqin GU
;
Yuanhong XU
;
Ying HUANG
;
Yunzhuo CHU
;
Sufei TIAN
;
Jihong LI
;
Bixia YU
;
Cunshan KOU
;
Jilu SHEN
;
Wenhui HUANG
;
Xiuli YANG
;
Likang ZHU
;
Lin JIANG
;
Wen HE
;
Chunlei YUE
Author Information
- Publication Type:Journal Article
- Keywords: Haemophilus influenzae; Moraxella catarrhalis; β-lactamase; antimicrobial resistance
- From: Chinese Journal of Infection and Chemotherapy 2025;25(1):30-38
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the distribution and antimicrobial resistance profiles of clinically isolated Haemophilus influenzae and Moraxella catarrhalis in hospitals across China from 2015 to 2021,and provide evidence for rational use of antimicrobial agents.Methods Data of H.influenzae and M.catarrhalis strains isolated from 2015 to 2021 in CHINET program were collected for analysis,and antimicrobial susceptibility testing was performed by disc diffusion method or automated systems according to the uniform protocol of CHINET.The results were interpreted according to the CLSI breakpoints in 2022.Beta-lactamases was detected by using nitrocefin disk.Results From 2015 to 2021,a total of 43 642 strains of Haemophilus species were isolated,accounting for 2.91％of the total clinical isolates and 4.07％of Gram-negative bacteria in CHINET program.Among the 40 437 strains of H.influenzae,66.89％were isolated from children and 33.11％were isolated from adults.More than 90％of the H.influenzae strains were isolated from respiratory tract specimens.The prevalence of β-lactamase was 53.79％in H.influenzae strains.The H.influenzae strains isolated from children showed higher resistance rate than the strains isolated from adults.Overall,779 strains of H.influenzae did not produce β-lactamase but were resistant to ampicillin(BLNAR).Beta-lactamase-producing strains showed significantly higher resistance rates to these antimicrobial agents than the β-lactamase-nonproducing strains.Of the 16 191 M.catarrhalis strains,80.06％were isolated from children and 19.94％isolated from adults.M.catarrhalis strains were mostly susceptible to both amoxicillin-clavulanic acid and cefuroxime,evidenced by resistance rate lower than 2.0％.Conclusions The emergence of antibiotic-resistant H.influenzae due to β-lactamase production poses a challenge for clinical anti-infective treatment.Therefore,it is very important to implement antibiotic resistance surveillance for H.influenzae and guide rational antibiotic use.All local clinical microbiology laboratories should actively improve antibiotic susceptibility testing and strengthen antibiotic resistance surveillance for H.influenzae.
