The advancement of brain functional imaging in individuals diagnosed with major depressive disorder and their first-degree relatives
10.3760/cma.j.cn113661-20230613-00128
- VernacularTitle:抑郁症患者及一级亲属的脑功能影像研究进展
- Author:
Feng LI
1
;
Zhifang ZHANG
;
Qijing BO
;
Chuanyue WANG
Author Information
1. 首都医科大学附属北京安定医院 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室 北京脑重大疾病研究院精神分裂症研究所，北京100088
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
First-degree relatives;
Brain function;
Neuroimaging
- From:
Chinese Journal of Psychiatry
2023;56(5):395-400
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder is a prevalent and burdensome mental illness that exhibits a high degree of heritability. Despite this, the underlying neural mechanisms that contribute to its development remain unclear. To enhance our comprehension of the pathology and susceptibility mechanisms of major depressive disorder, this study aims to compare the neuroimaging characteristics of patients diagnosed with major depressive disorder and their first-degree relatives. The objective of this study is to conduct a comprehensive analysis and synthesis of brain functional images of individuals diagnosed with major depressive disorder, including those in the acute and remission stages, as well as their first-degree relatives, utilizing various prevalent neuroimaging modalities. Additionally, this study aims to identify potential avenues for future research in this area. This study shows that abnormalities in local brain functional activity and functional interactions of the cortical-limbic-cerebellar circuits are critical in intrinsic neural mechanisms of depression and their first-degree relatives, and this circuits is also a potential target for antidepressants. Future studies are needed to further clarify the role of unbalanced cortical-limbic-cerebellar circuits in the disease process of depression.
