Research progress in prevention and treatment of peripheral neuropathy associated with oxaliplatin
10.3760/cma.j.issn.1008-5734.2016.02.011
- VernacularTitle:奥沙利铂致周围神经病变及其防治研究进展
- Author:
Xuelan ZHANG
1
;
Xia ZHANG
Author Information
1. 030001 太原，山西医科大学第二临床医学院临床医学系2013级; 100007 北京军区总医院肿瘤内科诊治中心
- Publication Type:Journal Article
- Keywords:
Oxaliplatin;
Peripheral nerve injuries;
Drug toxicitY
- From:
Adverse Drug Reactions Journal
2016;18(2):132-136
- CountryChina
- Language:Chinese
-
Abstract:
Oxaliplatin is commonlY used in treatment or adjuvant therapY of metastatic colorectal cancer. Oxaliplatin-induced peripheral neuropathY is a sensorY neuropathY characterized bY peripheral neuritis with dose-limiting and dose-dependent manner. The incidence of acute oxaliplatin-induced peripheral neuropathY is 86% to 95% and its occurrence is related to the oxalate which is one of oxaliplatin metabolites in the bodY. The clinical manifestations are mainlY reversible extremities paresthesia and dYsesthesia induced or exacerbated bY the cold stimulation. Oxaliplatin-induced chronic peripheral neuropathY,with accumulative and reversible manner,maY be related to the drug-induced nerve cell damage and the change of pain signal modulation and transmission,and its incidence rate is dose-related. The clinical manifestations include peripheral sensorY function decrease or absence,upper and lower extremitY numbness,and even phYsical dYsfunction. The neurotoxicitY of oxaliplatin can be prevented or reduced bY the avoidance of the cold stimulation during treatment,appropriate extension of the drug infusion period and the application of certain drugs.
