Differences of brain gray matter volume and functional connectivity in adolescent female borderline personality disorder and correlation with dysregulation
10.3760/cma.j.cn113661-20230104-00003
- VernacularTitle:青少年女性边缘型人格障碍脑灰质体积及功能连接异常与情绪失调的关系
- Author:
Liping ZHANG
1
;
Chunyan YIN
;
Guoping HUANG
;
Yaming HANG
;
Ya XIE
;
Pei ZHANG
;
Yumin ZHANG
;
Minlu LIANG
;
Yun WU
;
Chun WANG
Author Information
1. 南京医科大学附属脑科医院，南京 210029
- Publication Type:Journal Article
- Keywords:
Borderline personality disorder;
Magnetic resonance imaging;
Gray matter volume;
Borderline Symptom List;
Functional connectivity
- From:
Chinese Journal of Psychiatry
2023;56(5):354-360
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the abnormal features of brain structure and functional connection (FC) in adolescent female patients with borderline personality disorder (BPD) and to explore the relationship between brain structure and clinical severity.Method:Eighteen female patients with BPD and 18 healthy controls matched with sex, age and education level aged 12—17 were examined by resting functional magnetic resonance imaging (fMRI). The differences of gray matter volume (GMV) and functional connection between the two groups were compared by voxel-based morphometric measurement and functional connection method, and t-test was used to compare the differences between the two groups. Spearman correlation analysis was used to analyze the correlation between abnormal brain regions, brain regions with different functional connections and Borderline Symptom List (BSL-23) scores. Result:The GMV of the left inferior temporal gyrus ( t=4.23), the right inferior temporal gyrus ( t=4.85), and the left middle orbital frontal gyrus ( t=4.16) were significantly larger in the BPD group than those in the healthy controls (GRF corrected voxel P<0.005, cluster P<0.05 two-tails). FC decreased in left inferior temporal gyrus and right middle temporal gyrus ( t=-6.20), increased in the left inferior temporal gyrus and the right fusiform gyrus ( t=5.75), the left inferior temporal gyrus and the left inferior parietal marginal angular gyrus ( t=4.38;GRF corrected voxel P<0.005, cluster P<0.05, two-tailed). In the BPD group, the increase in orbital frontal gray matter volume was negatively correlated with the emotional items BSL9 (tension; r=-0.523, P=0.023), BSL14 (rapid emotional changes; r=-0.549, P=0.018), BSL15 (tolerated pain; r=-0.589, P=0.010), BSL17 (vulnerable; r=-0.554, P=0.017), BSL5 (self-injury; r=-0.616, P=0.006) and BSL18 (suicide attraction; r=-0.661, P=0.003) in the BSL-23. Conclusion:There are differences in the GMV of the inferior temporal and the left middle orbital frontal lobe in adolescent female patients with BPD. The FC abnormalities of the left inferior temporal and right middle temporal gyrus, the left inferior temporal gyrus and the right fusiform gyrus, the left inferior temporal gyrus and the left inferior parietal marginal angular gyrus, especially the changes of GMV in the orbital frontal brain structure might participate in the pathological mechanism of emotion regulation injury in patients with BPD.
