Progress in studies on pharmacological action and safety of sodium valproate's metabolites 2-propyl-2-pentenoic acid

VernacularTitle:丙戊酸钠代谢产物2-丙基-2-戊烯酸的药理作用和安全性研究进展
Author: Longkuan LI ¹ ; Juan XIE ¹
Author Information

1. 贵州省人民医院药剂科, 贵阳,550002
Publication Type:Journal Article
Keywords: Valproic acid; Metabolic detoxication,drug
From: Adverse Drug Reactions Journal 2015;(6):436-439
CountryChina
Language:Chinese
Abstract: Valproic acid is metabolized via β-oxidation in the body and produces 2-propyl-2-pentenoic acid(2-ene-VPA)which has antiepileptic activity and sedation but also has certain hepatotoxicity and neurotoxicity. 2-ene-VPA is eliminated slowly than VPA and has a high binding protein as to VPA. Hepatotoxicity of 2-ene-VPA is lesser than VPA but also can interfere with the normal oxidation of fatty acid. The valproic acid-induced hyperammonemic encephalopathy may refer to the accumulation of 2-ene-VPA in brain. The pharmacological action and safety of 2-ene-VPA need more pre-clinical evaluation.