Interferon-induced colonic lesions:clinical features,prevention,and treatment

VernacularTitle:干扰素相关结肠病变的特点及防治
Author: Yuyong JIANG ¹ ; Peipei MENG ; Fei WANG ; Yuanyuan SONG
Author Information

1. 首都医科大学附属北京地坛医院中西医结合中心
Publication Type:Journal Article
Keywords: Interferons; Inflammatory bowel diseases
From: Adverse Drug Reactions Journal 2015;(6):440-443
CountryChina
Language:Chinese
Abstract: The interferon is a commonly used drug which is used to treat viral hepatitis. Due to its significant role in the regulation of immune system,it can conduce to inflammatory bowel diseases,such as ulcerative colitis,Crohnˊs disease,and ischemic colitis. Interferon-related ulcerative colitis is more common, generally occurs from two weeks to several years after interferon therapy,the patients complain of abdominal pain and diarrhea,mucus stool is the main manifestation. A total colonoscopy shows diffuse mucosal edema, ulcer,and hyperemia. The patients are treated with mesalazine,sulfasalazine or glucocorticoids. Some patients may continue interferon therapy after the symptoms improved. Interferon-related Crohn's disease is rare and the prognosis is poor. Interferon-related ischemic colitis lesions generally are confined to the descending colon,long-term ulcers,mucosal edema and erosion bleeding. The symptoms are relieved within 2 weeks after interferon discontinuation and symptomatic therapy. Then interferon therapy can be continued.