Anaphylactic shock due to latamoxef sodium in a child
10.3760/cma.j.issn.1008-5734.2015.06.021
- VernacularTitle:拉氧头孢钠致儿童过敏性休克
- Author:
Xuli ZHONG
1
;
Junli ZHANG
1
Author Information
1. 首都儿科研究所附属儿童医院药学部, 北京,100020
- Publication Type:Journal Article
- Keywords:
Moxalactam;
Anaphylaxis;
Child
- From:
Adverse Drug Reactions Journal
2015;(6):466-467
- CountryChina
- Language:Chinese
-
Abstract:
A 9-year-old girl with recurrent urinary tract infection received an IV infusion of latamoxef sodium 1. 5 g twice daily. About 2 minutes after the first latamoxef sodium infusion,the girl developed generalized skin flushing and itching,blurred vision,lip cyanosis and chest congestion. Her heart rate was 70 beats/ min,blood pressure was 58 / 27 mmHg and breathing rate was 25 / min. Latamoxef sodium was stopped immediately and she was given oxygen inhalation through nasal tube and electrocardiographic monitoring. She was treated with an intravenous bolus of adrenaline 0. 3 mg,an intravenous bolus of promethazine hydrochloride 25 mg,an IV infusion of 0. 9% sodium chloride injection 500 ml,oral chlorphenamine 8 mg and an IV infusion of methylprednisolone 80 mg. About 1 hour later,her blood pressure was 80-90 / 41-47 mmHg. Adrenaline 1 μg/(kg·min)via IV pump was given. Two minutes later, her blood pressure increased to 157 / 78 mmHg and the heart rate was 88 beats/ min. Adrenaline was gradually reduced and stopped.
