Analysis of resting-state functional connectivity effects in untreated patients with unipolar and bipolar depressive disorders
10.3760/cma.j.cn113661-20221202-00330
- VernacularTitle:未服药单相和双相抑郁障碍患者静息态核心脑网络效应连接分析
- Author:
Fan YANG
1
;
Zhifang ZHANG
;
Yuan ZHOU
;
Ling ZHANG
;
Qian ZHAO
;
Gang WANG
Author Information
1. 首都医科大学附属北京安定医院 国家精神疾病医学中心 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室，北京 100088
- Publication Type:Journal Article
- Keywords:
Depression;
Magnetic resonance imaging;
Brain networks;
Effective connectivity
- From:
Chinese Journal of Psychiatry
2023;56(4):256-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the similarity and differences in the intra-and inter-network connectivity effects of the Executive Control Network (ECN), Salience Network (SN) and Default Mode Network (DMN) in patients with unipolar depression (UD) and bipolar depression (BD) patients at resting state. Additionally, the study aims to explore the correlations between clinical symptoms and connectivity differences in the two types of patients.Methods:From March 2021 to June 2022, resting-state functional magnetic resonance imaging (fMRI) and T 1 structural imaging data were collected from 39 UD patients, 24 BD patients and 50 healthy controls (HC) who were between 18-35 years of age, without being treated by medications. Spectral dynamic causal modeling (spDCM) analysis investigated differences in intra-and inter-network connectivity effects between the two patient groups. Furthermore, the canonical correlation analysis method was used to detect correlations between clinical symptoms and connectivity differences. Results:Compared to the HC, both of UD and BD groups showed decreased excitatory effect within the SN (effective connectivity value=-0.04, posterior probability( Pp)=1.00), with the UD group showing a more pronounced reduction (effective connectivity value=0.02, Pp=0.97). The differences in connectivity effects between the two patient groups were extensive. Further correlation analyses found that the decreased connectivity effects in the BD, compared to the UD group, were associated with depressive (χ 2=1 696.10, P<0.01) and manic symptoms (χ 2=1 699.30, P<0.01)symptoms in the BD group, as well as depressive symptoms in the UD group (χ 2=1 696.10, P<0.01). Conclusions:UD and BD patients exhibit shared and distinct core brain connectivity characteristics, and the differing features correlate with the severity of depressive symptoms in both UD and BD patients.
