Ataxia induced by combination of carbamazepine and erythromycin cyclocarbonate
10.3760/cma.j.issn.1008-5734.2015.06.015
- VernacularTitle:卡马西平与环酯红霉素合用致共济失调
- Author:
Hong AN
1
;
Liyong WU
1
;
Na YIN
1
;
Haiqing SONG
1
;
Jianping JIA
1
Author Information
1. 首都医科大学宣武医院神经内科, 北京,100053
- Publication Type:Journal Article
- Keywords:
Carbamazepine;
Erythromycin cyclocarbonate;
Ataxia
- From:
Adverse Drug Reactions Journal
2015;(6):456-457
- CountryChina
- Language:Chinese
-
Abstract:
A 36-year-old women with epilepsy received oral carbamazepine 0. 4 g twice daily for ten years(blood concentration of carbamazepine ranged from 5. 5 to 9. 5 μg/ ml)and received oral erythromycin cycloocarbonate 0. 5 g twice daily for wheezing and infection. Six to seven hours after first dose of oral erythromycin cyclocarbonate,she developed acute dizziness and walking instability,aggravated during the next day,and accompanied by blurred vision. On the third day,the patient's dizziness aggravated further, she could not stand up and walk independently and developed nausea and vomiting. Blood concentration of carbamazepine was 24. 1 μg/ ml. It was highly suspected that the patient' s ataxia was caused by the interaction of carbamazepine and erythromycin cyclocarbonate. Erythromycin cyclocarbonate was immediately discontinued,while the dosage of carbamazepine was reduced. At the same time intravenous fluid and symptomatic treatments were given. Twenty-four hours after treatments,the patient's dizziness was obviously improved. Five days later,her ataxia disappeared and her blood concentration of carbamazepine was 10. 3μg/ ml. At 3 months of follow-up,dizziness and ataxia did not recur.
