Impact of microbiota-gut-brain axis on neuroinflammation after post-cardiac arrest brain injury
10.3969/j.issn.1006-5725.2025.06.021
- VernacularTitle:微生物-肠-脑通讯对心脏骤停后脑损伤神经炎症的影响
- Author:
Haojun ZHANG
1
;
Mei JING
;
Yufeng ZHU
;
Tianpeng XU
;
Xi CHEN
;
Rongyi SHI
;
Yi SHAN
Author Information
1. 海军特色医学中心急诊医学科(上海 200052)
- Publication Type:Journal Article
- Keywords:
cardiac arrest;
post-cardiac arrest brain injury;
short-chain fatty acid;
microbiota-gut-brain axis
- From:
The Journal of Practical Medicine
2025;41(6):911-915
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac arrest is a major health event that poses a major threat to human life and health.Post-cardiac arrest brain injury is the main adverse prognostic factor and cause of death in patients who experience cardiac arrest.Currently,the therapeutic methods and effects are limited.In recent years,with the in-depth research on microbiota-gut-brain communication,it has been found that intestinal microbiota and their metabolites may play a role in the regulation of neuroinflammation in post-cardiac arrest brain injury.Short-chain fatty acids are the key substances in microbiota-gut-brain communication,and the mechanism involves immune,endocrine and neuroregulatory pathways.Supplementation of short-chain fatty acid-producing bacteria or short-chain fatty acids can improve intestinal flora disorder and reduce neuroinflammation after cardiopulmonary resuscitation.As a key mediator in microbial-gut-brain communication,short-chain fatty acids have great potential for the treatment of brain injury after cardiac arrest.This review explores the role and regulatory mechanism of microbiota-gut-brain communication in the neuroinflammation of brain injury after cardiopulmonary resuscitation through immune,endocrine and neuro-regulatory pathways,providing a new idea for the treatment of post-cardiac arrest brain injury.
