Liver injury caused by leuprorelin acetate microspheres sustained release for injection
10.3760/cma.j.issn.1008-5734.2015.06.017
- VernacularTitle:注射用醋酸亮丙瑞林缓释微球致肝损伤
- Author:
Xiaolei MA
1
;
Lanyue ZHANG
1
;
Ran WANG
1
;
Xin FENG
1
Author Information
1. 100020,首都医科大学附属北京妇产医院药事部
- Publication Type:Journal Article
- Keywords:
Leuprorelin;
Drug-induced liver injury
- From:
Adverse Drug Reactions Journal
2015;(6):459-460
- CountryChina
- Language:Chinese
-
Abstract:
A 30-year-old female patient with uterine fibroids and endometriosis received subcutaneous injection of leuprorelin acetate microspheres sustained release 3. 75 mg. One week later,the patient developed weakness,tired of greasy foods,decreased food intake,and occasional nausea. Laboratory tests revealed the following results:alanine transaminase(ALT)1 108 U/ L,aspartate transaminase(AST) 612 U/ L,total bilirubin( TBil)141 μmol/ L,direct bilirubin( DBil)115 μmol/ L,albumin 43 g/ L, gamma glutamyltranspeptidase(γ-GT)188 U/ L,urine bilirubin + + . The patient was considered as liver injury induced by leuprorelin acetate microspheres sustained release for injection. She received symptomatic treatments which included hepatoprotective,jaundice-relieving and cholestasis-lessening regimens. Thirty days later,the laboratory tests showed ALT 5 U/ L,AST 17 U/ L,TBil 27 μmol/ L,DBil 11 μmol/ L,γ-GT 107 U/ L,and urine bilirubin negative.
