Research progress on transcranial alternating current stimulation for cognitive impairment in the elderly
10.3760/cma.j.cn113661-20221226-00346
- VernacularTitle:经颅交流电刺激治疗老年认知功能障碍的研究进展
- Author:
Zhangying WU
1
;
Xiaomei ZHONG
1
;
Yuping NING
1
Author Information
1. 广州医科大学附属脑科医院 广东省神经科学疾病研究重点实验室 神经致病基因与离子通道病省部共建重点实验室，广州 510370
- Publication Type:Journal Article
- Keywords:
Cognition disorders;
Transcranial alternating current stimulation;
Neuromodulation;
Cognitive;
The elderly
- From:
Chinese Journal of Psychiatry
2023;56(5):342-347
- CountryChina
- Language:Chinese
-
Abstract:
Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior by inducing local changes in neural oscillatory power and cross-frequency, cross-regional phase synchronization. It has enormous potential for cognitive research and brain condition treatment. Cognitive impairment in the elderly involves dysrhythmic neural activity within and between brain regions. tACS regulates single or nested brain rhythms to induce cell synchronization and desynchronization, enhancing local or distant synchronous activity in the cortical network to improve cognitive function. This review focuses on introducing the possible mechanisms, influencing factors of efficacy, and clinical applications for elderly cognitive impairment, as well as the development prospects of cross-frequency coupling and closed-loop modulation and other paradigms.
