Advances in the functional magnetic resonance imaging study of cognitive impairment in clinical high-risk for psychosis
10.3760/cma.j.cn113661-20220831-00244
- VernacularTitle:精神病临床高危综合征认知功能损伤的功能磁共振成像研究进展
- Author:
Guanfu WU
1
;
Huiru CUI
1
;
Xiaochen TANG
1
;
Lihua XU
1
;
Tianhong ZHANG
1
;
Jijun WANG
1
;
Yingying TANG
1
Author Information
1. 上海交通大学医学院附属精神卫生中心脑电影像研究室，上海 200030
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Clinical high risk syndrome for psychosis;
Cognition
- From:
Chinese Journal of Psychiatry
2023;56(1):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Attenuated psychotic symptoms and cognitive impairments characterize individuals at clinical high risk (CHR) for psychosis. Those who convert to schizophrenia during the follow-up often exhibit more severe cognitive impairments. Recently, task functional magnetic resonance imaging(fMRI) studies have provided imaging features for revealing the neurobiological basis of different cognitive function impairments, biomarkers for predicting conversion to psychosis, and potential targets for developing the early intervention. This review summarized the progress of fMRI studies focused on cognitive impairments, including the features of abnormal brain activities related to cognitive functions and clinical symptoms. The authors also looked at the possibility of predicting clinical conversion based on the fMRI features.
