Research progress on age-specific epigenetic mechanisms of major depressive disorder
10.3760/cma.j.cn113661-20220315-00059
- VernacularTitle:抑郁症不同年龄特征的表观遗传学机制研究进展
- Author:
Xiaodong SONG
1
;
Jiali HE
1
;
Sihui LYU
1
;
Shuming ZHONG
1
;
Yanbin JIA
1
Author Information
1. 暨南大学附属第一医院精神医学科，广州510630
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Age factors;
Biological markers;
Epigenetic
- From:
Chinese Journal of Psychiatry
2022;55(6):469-474
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder (MDD), is characterized by high incidence rate, high suicide rate, and high disability rate, however, the underlying pathogenesis of MDD is still unclear. Based on the diathesis-stress model of depression, epigenetic mechanisms strongly explain the integration of genes and environment in the development of depression. However, depression has a high degree of clinical heterogeneity, with individuals of different ages presenting different symptoms and epigenetic changes. As a dynamic molecular marker that varies with age and environmental experience, epigenetics helps to elucidate the unique and complex disease pathogenesis of depression at different ages. Therefore, this paper aims to review relevant epigenetic studies of depression at different ages of onset to explore its potential age-specific association mechanism, in order to provide a theoretical basis for the formulation of accurate intervention measures for patients with MDD at different ages.
