Acute agranulocytosis caused by cinepazide maleate
10.3760/cma.j.issn.1008-5734.2014.06.012
- VernacularTitle:马来酸桂哌齐特致急性粒细胞缺乏症
- Author:
Min MAO
1
;
Mingjing SHAO
;
Haizhong JIA
;
Li HUANG
;
Jin LU
Author Information
1. 中日友好医院药学部临床药学室,北 京,100029
- Publication Type:Journal Article
- Keywords:
Cinepazide;
Agranulocytosis
- From:
Adverse Drug Reactions Journal
2014;(6):370-371
- CountryChina
- Language:Chinese
-
Abstract:
An 82-year-old male patient with cerebral infarction received an IV infusion of cinepazide maleate 320 mg + 0. 9% sodium chloride injection once daily for 30 consecutive days. The patient' s neutrophil count(NEUT)was 5. 7 × 109 / L before treatments and 2. 4 × 109 / L on day 28 of treatments. An interval of 5 days later,cinepazide maleate was given again at the same dosage. On day 6 of second use of cinepazide maleate,the patient's NEUT decreased to 0. 2 × 109 / L. Cinepazide maleate was stopped and mecobalamin(500 μg,twice daily),folic acid(5 mg,once daily),and leucogen(20 mg,twice daily) were given. Two days later,the patient's NEUT decreased to 0. Recombinant human granulocyte colony stimulating factor 200 μg twice daily was injected subcutaneously. Two days later,the patient' s NEUT increased to 4. 5 × 109 / L. The patient received cinepazide maleate combined with 15 kinds of drugs at the same time because he suffered from several kinds of diseases. During 18 months of follow-up,the patient did not take cinepazide maleate again and most other combination drugs were used continuously and neutropenia did not recur. It was considered that cinepazide maleate induced the patient's acute agranulocytosis.
