Hyponatremic encephalopathy caused by desmopressin acetate:two cases reports
10.3760/cma.j.issn.1008-5734.2014.06.016
- VernacularTitle:醋酸去氨加压素致低钠血症性脑病2例
- Author:
Siyun YANG
1
;
Xiaoyan HU
1
;
Yifei JI
1
;
Qiang SU
1
;
Zhaoping PAN
1
;
Zhongcai JIANG
1
Author Information
1. 637000,四川省南充市中心医院药剂科
- Publication Type:Journal Article
- Keywords:
Hyponatremia;
Desmopressin acetate
- From:
Adverse Drug Reactions Journal
2014;(6):377-378
- CountryChina
- Language:Chinese
-
Abstract:
Patient 1,a 25-year-old female with ectopic pregnancy received an IV infusion of desmopressin acetate 15 μg every 12 hours due to tubal embryo surgery incision and pelvic adhesion separation surgery. On day 2,about 30 minutes after the start of infusion,the patient developed delirium, confusion,convulsion, and trismus. Laboratory tests showed that serum sodium was 125 mmol/ L (preoperative serum sodium was 142 mmol/ L). Hyponatremic encephalopathy induced by desmopressin acetate was considered. Desmopressin acetate was withdrawn immediately and she was given sodium supplement. About 10 minutes later,the patient's symptoms relieved. She had consciousness and serum sodium level rose to 141 mmol/ L on the next day. Patient 2,a 42-year-old female patient received an IV infusion of desmopressin acetate 18 μg every 12 hours after radical treatment of perianal abscess. On day 4, the patient developed dizziness,sweating,tremor of hands,chills,and oliguria. On day 5,the patient developed nausea,upward deviation of the eyes,and muscular rigidity and clonus in both upper limbs. Laboratory tests showed that serum sodium was 124 mmol/ L(preoperative serum sodium was 141 mmol/ L). Her CT examination showed extensive edema in white matter of the cerebral hemisphere. Hyponatremic encephalopathy induced by desmopressin acetate was considered. Desmopressin acetate was stopped and she was given symptomatic treatments such as sodium supplement. One day later,the patient' s symptoms disappeared and her serum sodium increased to 138 mmol/ L.
