Anaphylaxis,serious thrombocytopenia,and coagulation disorders induced by iohexol injection
10.3760/cma.j.issn.1008-5734.2014.06.017
- VernacularTitle:碘海醇注射液致过敏反应和严重血小板减少及凝血功能异常
- Author:
Jiesong WANG
1
;
Chaoli ZHANG
;
Jun FEI
;
Yajun XIE
;
Xiaochan GUAN
;
Jiuhong WU
Author Information
1. 解放军第三〇六医院药学部, 北京,100101
- Publication Type:Journal Article
- Keywords:
Iohexol;
Anaphylaxis;
Thrombocytopenia;
Blood coagulation
- From:
Adverse Drug Reactions Journal
2014;(6):379-380
- CountryChina
- Language:Chinese
-
Abstract:
A 63-year-old female patient underwent coronary CT angiography and received an intravenous iohexol injection(350 mg/ ml )80 ml as the contrast agent. At the sixth minutes of observation after CT test completion,the patient developed palm itching,bilateral conjunctival congestion and edema, sweating,vertigo,nausea,and vomiting a small amount of gastric contents and then followed by lip cyanosis, facial edema,cold limbs,skin ecchymosis,and bleeding the injection site. Blood gas analysis showed an oxygen saturation of 0. 83 and an oxygen partial pressure of 47 mmHg. About an hour after CT scan,the laboratory test revealed the following levels:blood platelet count 19 × 109 / L,prothrombin time(PT)18 s, and thrombin time( TT)6 s. Treatments with anti-anaphylaxis,coagulation factor supplementation,and correction of acidosis and electrolyte disorder were given. After 7. 5 hours after CT scan,her blood platelet count was 8 ×109 / L. The next day,large pieces of skin ecchymosis appeared in many parts of her body,a body temperature reached 38. 1 ℃ and a blood platelet count was 6 × 109 / L. Symptomatic and supportive therapy was continued and her condition gradually improved. On day 4,she presented with normal temperature,disappeared facial edema,and relief of skin ecchymosis. On day 6,her level of blood platelet and all the values of coagulation functions returned to normal.
