Furazolidone-induced peripheral neuropathy and mental disorders
10.3760/cma.j.issn.1008-5734.2014.06.018
- VernacularTitle:呋喃唑酮过量致周围神经病和精神障碍
- Author:
Weibi CHEN
1
;
Lehong GAO
1
Author Information
1. 首都医科大学宣武医院神经内科, 北京,100053
- Publication Type:Journal Article
- Keywords:
Furazolidone;
Peripheral nervous system diseases;
Mental disorders
- From:
Adverse Drug Reactions Journal
2014;(6):381-382
- CountryChina
- Language:Chinese
-
Abstract:
A 67-year-old woman was given furazolidone 0. 6 g daily for gastritis. About one month after drug use,the patient developed rashes and itching on many parts of her body. About 40 days after drug use,symmetric numbness appeared in the area of her limbs and progressed to appear around the mouth as well as in tongue. About 50 days after drug use,she experienced dizziness and unstable walking accompanied gradually by hyperaction,a few of visual and auditory hallucination,and occasional involuntary shaking of her both upper extremities. About 60 days after drug use,the patient had taken furazolidone 36 g in total and stopped the drug. Electromyography test showed peripheral neurogenic damage. She was given an intravenous infusion of dexamethasone,thioctic acid,ganglioside,and compound coenzyme combined with intramuscular vitamin B1 and mecobalamine. On day 14 of therapy,her mental state and walking normalized,dizziness and numbness around the mouth and of tongue improved remarkably. At follow up after half a year,the patient had only light numbness in the acra of her limbs and skin pigmentation and others returned to normal.
