Study advances for efficacy and safety of polymyxins
10.3760/cma.j.issn.1008-5734.2014.05.012
- VernacularTitle:多黏菌素类药物疗效和安全性研究进展
- Author:
Ruya GAO
1
;
Kongcai ZHU
;
Xin HU
;
Guoying CAO
Author Information
1. 100730 北京医院药学部; 北京大学医学部药事管理与临床药学系
- Publication Type:Journal Article
- Keywords:
Polymyxins;
Treatment outcome;
Safety
- From:
Adverse Drug Reactions Journal
2014;(5):297-299
- CountryChina
- Language:Chinese
-
Abstract:
Polymyxin E and polymyxin B were the polypeptide antibiotic which were obtained from the Bacillus polymyxa medium. They were used to treat the resistant bacterial infection with Pseudomonas aeruginosa,Acinetobacter baumannii and Klebsiella pneumonia. The adverse reactions of polymyxin E were renal toxicity and nervous system toxicity. Age,dose and the combination with other drugs are the risk factors of renal toxicity. Combination with antioxidant,free radical scavenger and some Chinese medicine with protective effect on the kidney may reduce the renal toxicity of polymyxin E and improve the curative effect. Patients with renal insufficiency do not need to adjust the dose when they used polymyxin E and polymyxin B. Novel derivatives of polymyxin had lower renal toxicity.
