Rhabdomyolysis due to concomitant use of Zhibituo(脂必妥)and cyclosporin
10.3760/cma.j.issn.1008-5734.2014.05.014
- VernacularTitle:脂必妥与环孢素联用致横纹肌溶解症
- Author:
Xiangyu LIANG
1
;
Lin DU
;
Limin CHAI
;
Yamei XU
Author Information
1. 100700,北京中医药大学东直门医院针灸科
- Publication Type:Journal Article
- Keywords:
Zhibituo;
Cyclosporine;
Rhabdomyolysis
- From:
Adverse Drug Reactions Journal
2014;(5):301-302
- CountryChina
- Language:Chinese
-
Abstract:
A 66-year-old woman received Zhibituo 0. 35 g thrice daily by mouth for hypirlipidemia. Four days after the drug administration,the patient developed ache and weakness of deltoid;25 days later, the patient developed generalized aching pain,weakness,and hard to walk up and down stairs;on 4 weeks of the drug treatment,laboratory testing showed the following values:creatine kinase( CK)>6 400 U/L, creatine kinase isoenzyme(CK-MB)of 150. 7 U/L,lactic acid dehydrogenase(LDH)611 U/L,alanine aminotransferase(ALT)52 U/L,aspartate aminotransferase(AST)121 U/L,blood urea nitrogen 10. 1 mmol/L,and creatinine 106 μmol/L. Rhabdomyolysis was diagnosed. The patient received cyclosporine for aplastic anemia for a long time. It was considered that the interaction between Zhibituo and cyclosporin induced the rhabdomyolysis. Zhibituo was stopped and fluid replacement,diuretic,and liver-protective drugs were given. Five days later,the symptoms of generalized aching pain and weakness relieved obviously and CK level decreased to 1 170 U/L. Ten days later,the symptoms of generalized aching pain and weakness disappeared completely and the levels of CK,CK-MB,LDH,ALT,and AST were 59 U/L,6. 3 U/L,173 U/L,17 U/L,and 16 U/L,respectively.
