Numbness of extremities,tremor,and dyspnea induced by montelukast sodium

VernacularTitle:孟鲁司特钠致四肢麻木震颤和呼吸困难
Author: Sanlan WU ¹ ; Dongsheng CHEN ¹
Author Information

1. 华中科技大学同济医学院附属协和医院药剂科, 武汉,430022
Publication Type:Journal Article
Keywords: Montelukast sodium; Numbness of extremities; Tremor; Dyspnea
From: Adverse Drug Reactions Journal 2014;(5):303-304
CountryChina
Language:Chinese
Abstract: A 45-year-old woman received an intravenous injection of levofloxacin( 0. 4 g,once daily),Suhuangzhike(苏黄止咳)capsules(3 capsules,thrice daily)by mouth,and montelukast sodium (10 mg at bedtime,once daily)by mouth for acute attack of chronic bronchitis. About 30 min after the first administration of montelukast sodium,the patient developed numbness of extremities and tremor,dyspnea, and generalized weakness,followed by nausea and vomiting and the symptoms lasted for about 2 hours without alleviating. Montelukast sodium was discontinued,levofloxacin and Suhuangzhike capsules were applied continuously,and symptomatic treatments were given at the same time. The numbness of extremities and tremor and dyspnea relieved,nausea and vomiting did not recur until 16 :00 of the following day.