Advances in polygenic risk scoring in schizophrenia
10.3760/cma.j.cn113661-20210812-00248
- VernacularTitle:多基因遗传风险评分在精神分裂症中的研究进展
- Author:
Zhengqian JIANG
1
;
Zhipeng WU
1
;
Yicheng LONG
1
;
Zhening LIU
1
Author Information
1. 中南大学湘雅二医院精神科 国家精神心理疾病临床医学研究中心，长沙 410011
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Polygenic risk score;
Exposome score
- From:
Chinese Journal of Psychiatry
2022;55(3):214-219
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia is a complex mental disorder influenced by many common genetic variants. Studying the genetic characteristics of schizophrenia is helpful for early prevention and individualized treatment. Previous studies on single or several gene variants in mental disorders achieved limited explanatory power. The polygenic risk score (PRS) recently promised to quantify the genetic risk of polygenic diseases by integrating the risk of all identified genetic variation loci, which has already been used to investigate on clinical features, neuroimaging and drug therapy for schizophrenia. Besides, the combination of PRS and exposome score (ES) could capture the joint effect of gene-environment interaction. Therefore, this current study systematically reviewed these applications of PRS in schizophrenia-related investigations, aiming to provide new ideas for the prevention and treatment of schizophrenia.
