Advantage of advanced diffusion weighted imaging over single index diffusion weighted imaging in distinguishing low-grade transitional zone prostate cancer from benign prostatic hyperplasia with inflammation
10.3969/j.issn.1002-1671.2025.03.019
- VernacularTitle:高级扩散加权成像较单指数扩散加权成像在鉴别低级别移行带前列腺癌与前列腺增生伴炎症的优势
- Author:
Huipeng REN
1
;
Qinyun WAN
;
Boyun WU
;
Juanhong YANG
;
Hongzhe TIAN
;
Zhuanqin REN
;
Qing FAN
Author Information
1. 宝鸡市中心医院医学影像科,陕西 宝鸡 721008
- Publication Type:Journal Article
- Keywords:
prostate cancer;
benign prostatic hyperplasia;
prostatitis;
magnetic resonance imaging;
diffusion weighted imaging
- From:
Journal of Practical Radiology
2025;41(3):442-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the advantage of advanced diffusion weighted imaging(DWI)over single index DWI in distin-guishing low-grade transitional zone prostate cancer(TZ-PCa)from benign prostatic hyperplasia(BPH)with inflammation.Methods Thirty-two patients with low-grade TZ-PCa(low-grade TZ-PCa group)and 38 patients with BPH with inflammation(BPH with inflammation group)confirmed by pathology were selected.All patients underwent routine MR sequence,single index DWI,and advanced DWI[including introvoxel incoherent motion diffusion weighted imaging(IVIM-DWI),stretched-exponential model(SEM),diffu-sion kurtosis imaging(DKI)]sequences scans.The related parameters of the lesion area[including apparent diffusion coefficient(ADC),diffusion coefficient(D),distributed diffusion coefficient(DDC),and mean kurtosis(MK)values]were measured.Independ-ent sample t-tests were used to compare differences in parameters values between the two groups.The receiver operating characteris-tic(ROC)curve was used to calculate the area under the curve(AUC)of varous parameters values in the differential diagnosis of low-grade TZ-PCa and BPH with inflammation.The difference in AUC between advanced DWI and single index DWI was compared using Z-test.Results The ADC,D,and DDC values of the low-grade TZ-PCa group were lower than those of the BPH with inflammation group(P<0.05).The MK value of the low-grade TZ-PCa group was higher than that of the BPH with inflammation group(P<0.05).The D,DDC,and MK values,and a combination of these parameters(D+DDC+MK)exhibited high diagnostic effi-cacy(all AUC>0.9).The diagnostic efficacy of these parameters was significantly higher than that of the ADC value(AUC 0.902,0.904,0.966,0.994 vs 0.725,all P<0.05).The combined param-eter demonstrated the highest AUC.Although the diagnostic efficacy of the combined parameter was not statistically different from the individual D,DDC,and MK values(P>0.05),the diagnostic specificity was significantly improved compared to the individual parame-ters.Conclusion Advanced DWI(IVIM-DWI,SEM,DKI)has a higher diagnostic efficacy in distinguishing low-grade TZ-PCa from BPH with inflammation than single index DWI.Combining the parameters(D+DDC+MK)further improves diagnostic specificity.
