The progress of RNA splicing and splicing factors in the atherogenesis
10.20039/j.cnki.1007-3949.2025.02.001
- VernacularTitle:RNA剪接和剪接因子在动脉粥样硬化发生中的研究进展
- Author:
Huimin GAO
1
;
Bin GENG
1
Author Information
1. 北京协和医学院 中国医学科学院阜外医院高血压中心 心血管疾病国家重点实验室 国家心血管病中心,北京市 102300
- Publication Type:Journal Article
- Keywords:
RNA splicing;
alternative splicing;
splicing factor;
atherosclerosis
- From:
Chinese Journal of Arteriosclerosis
2025;33(2):93-101
- CountryChina
- Language:Chinese
-
Abstract:
RNA splicing is an important process for eukaryotes to regulate gene expression.Alternative splicing allows organisms to produce multiple functional RNAs and proteins from a single transcript,thereby expanding the applica-tion of genetic information.Moreover,alternative splicing makes it a reality that limited numbers genes can express nu-merous complex proteins.More and more studies reveal that incorrect splicing is closely associated with human diseases including cardiovascular diseases.This review provides an overview of the definition and mechanism of RNA splicing,as well as the role of alternative splicing in the pathogenesis of atherosclerosis.
