Analysis of clinicopathological and endoscopic features and endoscopic efficacy of early gastroesophageal junction cancer
10.3760/cma.j.cn321463-20240924-00292
- VernacularTitle:早期食管胃结合部癌的临床病理和内镜表现特点及内镜手术效果分析
- Author:
Ying ZHOU
1
;
Qi JIANG
;
Baisheng CHEN
;
Xia WU
;
Qiuli JIANG
;
Pinghong ZHOU
;
Weifeng CHEN
Author Information
1. 复旦大学附属中山医院（厦门）内镜中心，厦门 361015
- Publication Type:Journal Article
- Keywords:
Digestive system neoplasms;
Gastroesophageal junction;
Early cancer;
Endoscopic submucosal dissection;
Clinical features
- From:
Chinese Journal of Digestive Endoscopy
2025;42(6):487-490
- CountryChina
- Language:Chinese
-
Abstract:
To explore the clinicopathological characteristics, endoscopic manifestations, and efficacy of endoscopic procedure for early gastroesophageal junction cancer, a retrospective analysis was conducted on the patients who underwent endoscopic submucosal dissection (ESD) and pathologically confirmed early cancer of the gastroesophageal junction at Zhongshan Hospital, Fudan University and Xiamen Branch from November 2014 to October 2021. The pathological and gastroscopic features, as well as short-term efficacy of ESD were analyzed. Among the 401 patients, there were 332 males with the age of 66.02±7.93 years, and 69 females with the age of 66.26±9.31 years. The male-to-female ratio was 4.8∶1. Siewert type Ⅱ accounted for 70.82% (284/401). Lesions involving the lesser curvature accounted for 57.10% (229/401). Endoscopic manifestation of mucosal erythema accounted for 96.26% (386/401). Lesion morphology of 0-Ⅱc type accounted for 38.15% (153/401) and tubular adenocarcinoma accounted for 86.53% (347/401). The en bloc resection rate of ESD was 99.75% (400/401), with a curative resection rate of 72.82% (292/401). It is indicates that early gastroesophageal junction cancer predominantly occurs in middle-aged and elderly males. It is mostly Siewert type Ⅱ, and involves the lesser curvature, and primarily presents as type 0-Ⅱc morphology. The lesions are most commonly manifested as mucosal redness and are predominantly moderately to well-differentiated adenocarcinomas. ESD demonstrates a safe and effective therapeutic approach for early gastroesophageal junction cancer.
