Phenoconversion of drug-metabolizing enzymes and pharmacotherapy of mental disorders
10.3760/cma.j.cn113661-20210623-00201
- VernacularTitle:药物代谢酶的表型转化与精神药物治疗
- Author:
Fan MOU
1
;
Xue ZHAO
;
Huafang LI
;
Shunying YU
Author Information
1. 上海交通大学医学院附属精神卫生中心遗传室，上海 200030
- Publication Type:Journal Article
- Keywords:
Psychotropic drugs;
Drug-metabolizing enzymes;
Phenoconversion
- From:
Chinese Journal of Psychiatry
2022;55(2):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Phenoconversion of drug-metabolizing enzymes refers to the phenomenon that the phenotype of drug-metabolizing enzymes changes temporarily under specific non-genetic factors. Medicines and diseases are the main factors that cause phenoconversion. If its potential effects are ignored, it is easy to lead to poor clinical treatment effects, adverse drug reactions, and other risks. Most psychotropic medications, especially antidepressants, have different inhibitory effects on metabolic enzymes, which can easily cause phenotypic transformation. Therefore, phenoconversion is an important aspect of individual drug therapy for patients with mental disorders. This article reviewed the progress in the study on phenoconversion of drug metabolism enzymes in psychotropic medicines.
