The emerging role of lncRNA-mediated ceRNA regulatory networks in atherosclerosis-associated endothelial dysfunction
10.20039/j.cnki.1007-3949.2025.02.011
- VernacularTitle:lncRNA介导的ceRNA调控网络在动脉粥样硬化相关内皮功能障碍中的研究进展
- Author:
Jinwen LUO
1
;
Min LIU
;
Min LI
;
Yanqiao YU
;
Dazhuo SHI
;
Xiaojuan MA
Author Information
1. 中国中医科学院西苑医院心血管病研究中心,北京 100091;杭州市红十字会医院心血管内科,浙江省 杭州市 310009
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
endothelial cell;
long non-coding RNA;
microRNA
- From:
Chinese Journal of Arteriosclerosis
2025;33(2):169-177
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial dysfunction is a pivotal contributor to atherosclerosis(As)pathogenesis.A comprehensive understanding of the mechanisms of endothelial dysfunction would provide novel insights into effective treatment of As.Recent advances in genome and transcripome technology have enabled researchers to further explore the molecular mecha-nisms of endothelial dysfunction.It has been found that the regulatory network of competitive endogenous RNA(ceRNA)mediated by long non-coding RNA(lncRNA)plays a key role in endothelial dysfunction.lncRNA acts as a"molecular sponge"for microRNA(miRNA)to block the post-transcriptional repression of miRNA on downstream target gene messen-ger RNA(mRNA)by binding to miRNA,thereby regulating the function and phenotypic conversion of endothelial cell(EC)lncRNA-miRNA-mRNA interactions are widely involved in play an essential role EC inflammatory responses,apopto-sis,autophagy,angiogenesis,and endothelial-mesenchymal transition(EndMT).Which suggests that it may be a poten-tial therapeutic targets for As.
