Bibliometric analysis on hepatotoxicity due to antifungal drugs
10.3760/cma.j.issn.1008-5734.2014.03.004
- VernacularTitle:抗真菌药肝毒性的文献计量学分析
- Author:
Yan BAI
1
;
Yue LI
1
;
Bin LIU
1
;
Kun WANG
1
;
Hekun MEI
1
;
Ying ZHANG
1
;
Jin WANG
1
;
Rui WANG
1
Author Information
1. 100853北京，解放军总医院药品保障中心，医务部医疗处，药物临床研究中心
- Publication Type:Journal Article
- Keywords:
Antifungal drugs;
Hepatotoxicity;
Bibliometric analysis
- From:
Adverse Drug Reactions Journal
2014;(3):134-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the research progress of hepatotoxicity due to antifungal drugs, in order to provide a reference for clinical safety use of antifungal drugs. Methods "Antifungal drugs" and"hepatotoxicity" were selected as the keywords,and PubMed,Embase,Web of Science,Chinese Academic Periodical Full-text Database China HowNet Chinese Academic Journal( CNKI ) and Chinese Biomedical Literature database( CBMdisc)were searched. All literature on hepatotoxicity due to antifungal drugs were selected. A database of literature accepted for final bibliometric study was established by using Microsoft Excel. The parameters of bibliometrics such as published time( years),the top 5 countries and institutes in publishing,literature′s type,published time( years),top 5 journals in publishing number,top 10 articles in terms of cited frequency were studied. The main content and hotspot of literature were analyzed. The clinical manifestations, mechanism, incidence and prophylactico-therapeutic measures of hepatotoxicity due to antifungal drugs were summarized. Results A total of 221 articals(193 in English,28 in Chinese)were enrolled in the study,of which 116 were original articles,49 reviews and 56 case reports. The published time of first original publication of hepatotoxicity due to antifungal drugs were 1976. The journal which published largest number of articles was Mycoses. The highest citation number of individual article was 531. The main clinical manifestations were weak,right upper quadrant pain,diarrhea,jaundice,cholestasis and fever. The severe cases could cause liver failure. Laboratory examination showed elevated serum transaminases,bilirubin, and alkaline phosphatase. The incidence of liver toxicity due to azole antifungals was higher,the incidence of liver toxicity due to amphotericin B was lower. The antifungal drugs should be used with caution in patients with hypohepatia. For the patients who used antifungal drugs for long time,the liver function should be monitored regularly. If liver injury occurs,the antifungal drugs should be stopped immediately. Some patients′liver function test results could return to the normal levels before administration of the symptomatic treatment and the supportive liver protection therapy. The mechanism of hepatotoxicity due to antifungal drugs was unknown,it may be related to the damage of cytoplasmic membrane structure and inhibition of metabolism in cytochrome P450 2D6 enzyme. Conclusions The research abroad on hepatotoxicity due to antifungal drugs are ahead of China. Hepatotoxicity due to antifungal drugs is partially reversible.
