Comparison and analysis of antimicrobial susceptibility of pathogens from infected patients in Departments of Internal Medicine and Surgery
10.3760/cma.j.issn.1008-5734.2014.03.007
- VernacularTitle:内外科患者感染病原菌对抗菌药物敏感性的对比分析
- Author:
Jianbang KANG
1
;
Zhihong TIAN
;
Xiaoxia LI
;
Runmei ZHANG
;
Jinju DUAN
;
Ruiqin ZHANG
Author Information
1. 山西医科大学第二医院药学部,太原,030001
- Publication Type:Journal Article
- Keywords:
Microbial sensitivity tests;
Anti-bacterial agents;
Pathogens
- From:
Adverse Drug Reactions Journal
2014;(3):147-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the species and susceptibility of pathogens isolated from patients hospitalized in Departments of Internal Medicine and Surgery, and provide scientific basis for reasonable application of antibacterials and prevention and control of drug-resistant bacteria. Methods The pathogen isolation and drug sensitive test reports were collected from inpatients in Departments of Internal Medicine and Surgery in Second Hospital of Shanxi Medical University in 2012. The specimens included urine,blood,secretions,sputum,feces,throat swabs,cerebrospinal fluid,and so on. The original data were analyzed by WHONET 5. 5 and SPSS 16. 0 software and the distribution and susceptibility of pathogens isolated from patients hospitalized in Departments of Internal Medicine and Surgery were compared. Results A total of 4 268 strains of bacteria were isolated from 4 092 patients. Of them,2 257 strains were isolated from 2 182 patients in the Department of Internal Medicine and 2 011 were isolated from 1 910 patients in the Department of Surgery. The top 5 bacteria in Department of Internal Medicine were Escherichia coli,Klebsiellapneumonia,Pseudomonas aeruginosa,Coagulase-positive Staphylococcus aureus, and Aerobacter cloacae. The top 5 bacteria in Department of Surgery were Escherichia coli,Pseudomonas aeruginosa,Klebsiellapneumonia, Acinetobacter baumannii,and Aerobacter cloacae. The antimicrobial susceptibility of some pathogens isolated from patients in Department of Internal Medicine were higher than that in Department of Surgery,they were as follows:Escherichia coli vs. cefoperazone/sulbactam,cefepime, ceftazidime,ceftriaxone,amd cefuroxime nitrofurantoin[62. 7%(271/432)vs. 58. 0%(202/348),65. 5%(283/432)vs. 55. 5%(193/348),63. 8%(275/431)vs. 53. 3%(185/347),41. 8%(180/431)vs. 34. 4%(120/349),34. 0%(146/430)vs. 26. 6%(93/349)];Enterobacter cloacae vs. cefepime[94. 4%(151/160)vs. 83. 3%(140/168)];Pseudomonas aeruginosa vs. amikacin[92. 2%(190/206)vs. 86. 1%( 230/267 )]; Acinetobacter baumannii vs. imipenem, meropenem, cefoperazone/sulbactam, ciprofloxacin,and minocycline[30. 1%(31/103)vs. 19. 0%(41/216),29. 7(30/101)vs. 17. 5%(38/217),19. 4%(20/103)vs. 10. 8%(23/213),19. 2%(19/99)vs. 9. 8%(20/204),23. 2%(22/95)vs. 11. 1%(22/198)]. The antimicrobial susceptibility of some pathogens isolated from patients in Department of Internal Medicine were lower than that in Department of Surgery,they were as follows:Staphylococcus aureus vs. trimethoprim/sulfamethoxazole,gentamicin,clindamycin[54. 8%(40/73)vs. 78. 9%( 71/90 ),50. 0%( 37/74 ) vs. 71. 3%( 62/87 ),28. 8%( 21/73 ) vs. 46. 6%( 41/88 )];Klebsiella pneumoniae vs. levofloxacin [ 77. 3%( 269/348 ) vs. 90. 5%( 239/264 )], Pseudomonas aeruginosa vs. tobramycin[81. 8%(148/181)vs. 88. 7%(235/265)]. The differences above mentioned were statistically significant(all P﹤ 0. 05). Conclusions The species of bacteria isolated from patients in Department of Internal Medicine and Surgery are different and the susceptibility of the same kind of bacteria to the same kind of antibacterial agent is also different. Clinician should use antibacterials rationally according to the results of drug sensitivity tests.
