A comparative study of modified multi-side hole nasobiliary drainage and percutaneous transhepatic cholangial drainage in the treatment of advanced cholangiocarcinoma
10.3969/j.issn.1002-1671.2025.03.027
- VernacularTitle:改良式多侧孔鼻胆管内引流与经皮经肝胆管引流术在晚期胆管癌治疗中的对比研究
- Author:
Huabo ZHOU
1
;
Yijia HE
1
;
Guangkuo LI
1
;
Ke SUN
1
;
Shuai YANG
1
;
Yue LI
1
;
Huan LI
1
Author Information
1. 成都市第二人民医院肝胆外科,四川 成都 610017
- Publication Type:Journal Article
- Keywords:
cholangiocarcinoma;
obstructive jaundice;
biliary drainage;
percutaneous transhepatic puncture
- From:
Journal of Practical Radiology
2025;41(3):478-481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of modified multi-side hole nasobiliary drainage(MHND)via the percuta-neous transhepatic cholangiography(PTC)route with traditional percutaneous transhepatic cholangial drainage(PTCD)for palliative treatment of patients with advanced obstructive cholangiocarcinoma.Methods A retrospective analysis was conducted on the data from 66 patients with advanced cholangiocarcinoma who underwent biliary drainage.Results Both groups normalize temperature and alleviate symptoms of acute cholangitis within 24 h post-puncture.There was no statistically significant difference in laboratory indicators such as white blood cell(WBC),total bilirubin(TBiL),alanine transaminase(ALT),aspartic transaminase(AST)at 48 h post-operation,and in the incidence of bile leakage,biliary peritonitis,and cholangitis during the postoperative hospital stay(P>0.05).However,the incidence of postoperative electrolyte disorders,gastrointestinal symptoms,and the recurrence rate of gastrointestinal symptoms during the follow-up period were significantly higher in the PTCD group compared to the MHND group,while the recur-rence rate of biliary tract infections was slightly higher in the MHND group compared to the PTCD group.The differences between the two groups were statistically significant(P<0.05).Conclusion Modified MHND shows better clinical efficacy in the treatment of patients with advanced tumor jaundice.Compared with traditional PTCD,it not only effectively reduces jaundice and relieves acute cholangitis but also significantly reduces gastrointestinal symptoms during the postoperative period,thereby improving the quality of life for patients.However,it is noteworthy that it may also increase the risk of biliary tract infections.
