Clinical application and adverse reactions of febuxostat
10.3760/cma.j.issn.1008-5734.2014.03.012
- VernacularTitle:非布司他临床应用及不良反应
- Author:
Xue YANG
1
;
Yu XUE
1
;
Hejian ZOU
1
Author Information
1. 复旦大学附属华山医院风湿科,上海,200040
- Publication Type:Journal Article
- Keywords:
Febuxostat;
Efficacy;
Safety
- From:
Adverse Drug Reactions Journal
2014;(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Febuxostat is a new type of selective xanthine oxidase inhibitor,which mainly be used for the treatment of hyperuricemia patients with gout symptoms. The recommended initial dose of febuxostat is 40 mg once daily. In the present,there is no sufficient evidence to demonstrate that the clinical effects of febuxostat in reducing the uric acid are better than that of allopurinol. However,it is reported that febuxostat in 80 mg has better treatment effects in gout patients with diabetes or≥65 years old. The common adverse reactions of febuxostat are liver dysfunction,diarrhea,headache,nausea,rash,and so on. The differences of adverse reactions in cardiovascular system between febuxostat and allopurinol are not statistically significant.
