The value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced MRI T1 mapping in the evaluation of liver function
10.3969/j.issn.1002-1671.2025.03.016
- VernacularTitle:钆塞酸二钠增强MRI T1 mapping成像评估肝功能的价值
- Author:
Haiyan ZHANG
1
;
Di MENG
;
Lingyun GAO
;
Zhen ZHONG
;
Zhanguo SUN
Author Information
1. 微山县人民医院影像科,山东 济宁 277600;济宁医学院临床医学院,山东 济宁 272029
- Publication Type:Journal Article
- Keywords:
T1 mapping imaging;
gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid;
liver function;
Child-Pugh score
- From:
Journal of Practical Radiology
2025;41(3):429-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical application value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced MRI T1 mapping in the evaluation of liver function.Methods Sixty-four patients who underwent enhanced MRI T1 mapping with Gd-EOB-DTPA and completed the laboratory examination of liver function within one week were prospectively enrolled.All patients were divided into normal control group(NCG),cirrhosis Child-Pugh A(CCA)group,cirrhosis Child-Pugh B(CCB)group,and cirrhosis Child-Pugh C(CCC)group.CCB+CCC groups were defined as a moderate and severe abnormal liver function group.The T1 mapping images of pre-enhanced,post-enhanced 10 min and 20 min were collected,and the T1 mapping val-ues of liver and spleen were measured.The ΔT1 and hepatocyte enhancement fraction(HEF)were calculated.The differences of parameters in different liver function groups were analyzed and compared,and the diagnostic efficacy of each index in distinguishing different liver function groups was evaluated.Results There were significant differences in T1plain scan,T110 min,T120 min,ΔT110 min,ΔT120 min,HEF10 min and HEF20 min among the three groups(P<0.05).The difference of T1plain scan between NCG and CCA groups,and between NCG and CCB+CCC groups was statistically significant(P<0.05).The area under the curve(AUC)of differentiating normal liver function group from abnormal liver function group was 0.761.There were significant differences in T110 min,T120 min,ΔT110 min,ΔT120 min,HEF10 min and HEF20 min between CCA and CCB+CCC groups.The AUC of differentiating the two groups was 0.757,0.820,0.735,0.820,0.790 and 0.853,respectively,and HEF20 min had the highest diagnostic efficacy.Conclusion Gd-EOB-DTPA enhanced MRI T1 mapping can be used as an effective method to evaluate liver function.
